IndraLab
Statements
sparser
"Oikawa et al. (2022) further confirmed KEAP1-OTUD1 interaction and showed that KEAP1 K63 ubiquitination levels were elevated in OTUD1-deficient mouse embryonic fibroblasts, while overexpression of wild-type OTUD1 (but not an ETGE-lacking mutant) reduced KEAP1 ubiquitination in HEK293T cells."
sparser
"OTUD1 interacts with Smurf1 and functions as a deubiquitinase to remove the K48-linked ubiquitination of Smurf1, prevent its self-ubiquitination degradation, and upregulate its protein level; whereas the binding of Ndfip1 to MAVS recruits Smurf1 to MAVS, and the interaction between Ndfip1 and Smurf1 enhances the self-ubiquitination (possibly k63-linked) and enzyme activity of Smurf1 ( xref ) ( xref , xref )."
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"For example, OTUD1 upregulates the protein levels of intracellular Smurf1 by removing the K48-linked polyubiquitin chains of Smurf1, and RNA virus infection promotes the binding of Smurf1 to MAVS, TRAF3, and TRAF6, which leads to ubiquitination-dependent degradation of the three proteins and subsequent potent inhibition of IFNs production (64)."
"Furthermore, <span class="match term0">OTUD1</span> induced upregulation of the E3 ubiquitin ligase <span class="match term1">Smurf1</span> by deubiquitinating <span class="match term1">Smurf1</span>, and <span class="match term1">Smurf1</span> degraded MAVS in MDBK cells in a ubiquitination-dependent manner, ultimately inhibiting IFN-I production"
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"For example, OTUD1 affects the inflammatory response by deubiquitinating the STAT3 gene and influences pro-inflammatory cytokine production by cleaving its ubiquitin chain through direct interaction with CARD9 (Chen et al., 2021); OTUD1 also affects IFN signaling and innate immune response by stabilizing TyK2 protein (Zhang et al., 2022)."
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"In addition, loss of OTUD1 reduced the c-Jun phosphorylation level in SKOV3, OVCAR8 and CAOV3 cells (Supplementary Fig. 2e), implying that OTUD1 probably regulates OSCS by activating the JNK/c-Jun pathway.Moreover, depletion of OTUD1 reduced the ASK1 phosphorylation level in SKOV3 and OVCAR8 cells (Supplementary Fig. 2f)."
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"As shown in Fig. 4g, after treating SKOV3 cells with doxorubicin (DOX) for 12 h, ectopic expression of OTUD1 but not Δ105–164 (M1) increased the phosphorylation levels of ASK1 at Thr838 and the expression levels of the downstream phosphorylated forms of JNK and c-Jun, all of which indicate ASK1 activation."
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"Despite significant advancements in the identification of potential molecular targets and signaling pathways within the realm of cardiac hypertrophy 34-37, the existing clinical pharmacological strategies for managing this condition remain unsatisfactory.To the best of our knowledge, this is the first study to demonstrate that OTUD1 promotes pathological cardiac hypertrophy by upregulating ASK1 phosphorylation."
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"In addition, loss of OTUD1 reduced the c-Jun phosphorylation level in SKOV3, OVCAR8 and CAOV3 cells (Supplementary Fig. 2e), implying that OTUD1 probably regulates OSCS by activating the JNK/c-Jun pathway.Moreover, depletion of OTUD1 reduced the ASK1 phosphorylation level in SKOV3 and OVCAR8 cells (Supplementary Fig. 2f)."
"Breast cancer metastasis suppressor <span class="match term0">OTUD1</span> deubiquitinates <span class="match term1">SMAD7</span>"
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"OTUD1 deubiquitinates the TGF-β inhibitor SMAD7 and inhibits p53, thereby increasing the cleavage of caspase-3 and PARP-dependent apoptosis and enhancing tumor suppression248 249.Context-dependent DUBs, such as OTUD3 and USP10, constitute the third type of DUBs that exhibit contradictory functions in various tumors."
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"These collective findings promoted us to investigate the regulatory mechanism by which deubiquitinase OTUD1 activates NRF2 in the pathogenesis of hepatic I/R injury.Here, we have demonstrated that OTUD1 functions as a specific DUB for NRF2, leading to the stabilization and activation of the NRF2/ARE pathway, thereby results in the reduction of oxidative stress, apoptosis and inflammation in I/R-challenged liver."
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"In short, OTUD1 prefers abolishing proteosome-mediated NRF2 degradation rather than modulating NRF2 function through removing K63 polyubiquitin scaffold.Due to its robust cytoprotective role in preventing oxidative stress and inflammation, NRF2 activation is considered a promising therapeutic strategy for numerous diseases characterized by oxidative stress [40]."
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"Co-immunoprecipitation of OTUD1 and PRDX4 complexes was performed by lysing RPMI8226 cells in immunoprecipitation buffer (20 mM TRIS, pH 7.5, 150 mM NaCl, 0.5% NP40) containing phosphatase and protease inhibitor cocktail (Thermo Fisher Scientific), 20 mM N-ethylmaleimide, and 5 mM iodacetamide for 1 h on ice."
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"Moreover, OTUD1 oe led to a higher amount of FL PRDX4 but not Δ1-38 PRDX4 in the ER fractions (Supplementary Fig. 5c, d), further suggesting that OTUD1 protects PRDX4 from ERAD.A previous study described OTUD2 (YOD1), a close homolog of OTUD1, as a non-selective regulator of protein retrotranslocation from ER."
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"Our findings indicated that the deletion of the OTU domain did not exhibit any pro-hypertrophic effects on the NRVMs (Figure S7), suggesting the critical role of OTU domain in OTUD1-induced cardiac hypertrophy.Given that DUBs play a role in the modulation of biological activities by influencing the degradation or function of substrate proteins, our subsequent investigation aimed to determine whether Otud1 could deubiquitinating pgam5."
"As a deubiquitinase, <span class="match term0">OTUD1</span> directly interacts with transcription factor <span class="match term1">IRF3</span> and removes the K63-linked poly-ubiquitin chains on <span class="match term1">IRF3</span> Lysine 98, which inhibits <span class="match term1">IRF3</span> nuclear translocation and transcriptional activity"
OTUD1 affects apoptotic process
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OTUD1 activates apoptotic process.
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OTUD1 inhibits apoptotic process.
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OTUD1 inhibits apoptotic process. 6 / 6
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"Cell samples were stained and incubated with Annexin V and PI, the apoptosis rate of the si-OTUD1 group was significantly higher than that of the NC group (P < 0.05, Figure 7B) according to the results of the flow cytometry assay (Figure 7A), demonstrating that OTUD1 gene can significantly inhibit fibroblast apoptosis."
OTUD1 affects Interferon
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OTUD1 inhibits Interferon.
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OTUD1 activates Interferon.
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"As an example of AIF posttranslational modifications, it was reported that the X-linked inhibitor of apoptosis (XIAP) ubiquitinates AIF at K255 and consequently regulates AIF pro-apoptotic features, rather than its proteasomal degradation or NADH oxidoreductase properties.78 79 On the other hand, OTU deubiquitinase 1 (OTUD1) directly deubiquitinates AIF at K244 and alters AIF binding to CHCHD4, resulting in impaired OXPHOS and swollen mitochondria lacking intact cristae."
OTUD1 affects cell population proliferation
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OTUD1 inhibits cell population proliferation.
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OTUD1 inhibits cell population proliferation. 10 / 10
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"OTUD1 negatively regulates the cell cycle to inhibit the abnormal proliferation of cancer cells, since OTUD1 interacts with phosphatase and tensin homolog (PTEN), a negative regulator of the AKT (also known as protein kinase B) and NF-κB signaling pathways, and regulates its stability (Figure 2C)."
OTUD1 activates cell population proliferation.
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"OTUD1 interacts with Smurf1 and functions as a deubiquitinase to remove the K48-linked ubiquitination of Smurf1, prevent its self-ubiquitination degradation, and upregulate its protein level; whereas the binding of Ndfip1 to MAVS recruits Smurf1 to MAVS, and the interaction between Ndfip1 and Smurf1 enhances the self-ubiquitination (possibly k63-linked) and enzyme activity of Smurf1 ( xref ) ( xref , xref )."
sparser
"Using both the K63-specific mutant and the K63R mutant of ubiquitin, we found that of these four YAP-interacting DUBs, only OTUD1 clearly reduced K63-linked ubiquitination of YAP (Supplementary Fig. xref ), while the other three DUBs (JOSD2, OTUD7B, and YOD1) substantially reduced non-K63-linked ubiquitination of YAP (Supplementary Fig. xref )."
OTUD1 affects Neoplasm Metastasis
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OTUD1 inhibits Neoplasm Metastasis.
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11
OTUD1 activates Neoplasm Metastasis.
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"Moreover, more studies need to be performed to determine whether OTUD1 exerts consistent roles in mice models.In conclusion, this investigation for the first time has elucidated that OTUD1 inhibits NSCLC cell progression including cell growth, migration and invasion by stabilizing and ubiqutinating the tumor suppressor, KLF4."
OTUD1 affects Hypertrophy
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OTUD1 activates Hypertrophy.
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OTUD1 inhibits Hypertrophy.
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"Thus, targeting CD36 can reshape the composition and function of T cells in the TME through the ferroptosis pathway.The ovarian tumor domain-containing protein 1 (OTUD1) is involved in the deubiquitination of iron-responsive element-binding protein 2 (IREB2), stabilizing IREB2 to enhance iron transport mediated by transferrin receptor 1 (TFR1)."
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"143
OTUD1 promotes the deubiquitination of IREB2, which inhibits the degradation of IREB2 protein and activates the expression of TFRC, thereby increasing the concentration of iron ions in tumor cells and enhancing the sensitivity to ferroptosis as well as the infiltration of CD8+ T cells, improving antitumor immune response."
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"Co-immunoprecipitation of OTUD1 and PRDX4 complexes was performed by lysing RPMI8226 cells in immunoprecipitation buffer (20 mM TRIS, pH 7.5, 150 mM NaCl, 0.5% NP40) containing phosphatase and protease inhibitor cocktail (Thermo Fisher Scientific), 20 mM N-ethylmaleimide, and 5 mM iodacetamide for 1 h on ice."
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"Importantly, AHI1 deficiency inhibited OTUD1-mediated both downregulation of Tyk2 ubiquitination (Fig. 5c) and upregulation of Tyk2 protein levels (Supplementary information, Fig. S5g), suggesting that OTUD1 regulates Tyk2 ubiquitination and protein levels dependently on AHI1.OTUD1 has been reported to be able to regulate both K48-linked and K63-linked ubiquitination of protein substrates."
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"In line with this, OTUD1 deficiency in both primary macrophages (Fig. 5b) and MEFs (Supplementary information, Fig. S5d), as well as A549 cells (Supplementary information, Fig. S5e), markedly improved Tyk2 ubiquitination levels, whereas OTUD1 overexpression inhibited Tyk2 ubiquitination (Fig. 5c; Supplementary information, Fig. S5f)."
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"It will be interesting to clarify the signaling crosstalk between different types of cells stimulated by different hormones in the future.In summary, we found that depression-elevated AVP induces AHI1 reduction in macrophages, which further disrupts the deubiquitinase OTUD1-mediated stabilization of cellular Tyk2, thus attenuating basal IFN-I signaling and host antiviral immune defense (Fig. 8h)."
OTUD1 affects immune response
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OTUD1 inhibits immune response.
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Mutated OTUD1 inhibits immune response. 2 / 2
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"Meanwhile, previous studies have demonstrated that Otud1 knockout mice were more susceptible to lipopolysaccharide (LPS)-induced sepsis [11], and loss-of-function mutations of OTUD1 enhanced immune response and were associated with autoimmunity [12], suggesting a potential role for OTUD1 in hepatic inflammation caused by I/R."
OTUD1 inhibits immune response. 2 / 2
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OTUD1 activates immune response.
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"Ectopic expression of OTUD1 could suppress TGF-beta signaling in control cells but barely showed effect in SMAD7 deficient cells; also knockdown of OTUD1 could promote TGF-beta signaling in control cells but not in SMAD7 deficient cells, suggesting thatinhibitory SMAD7 might be the major target of OTUD1 in the TGF-beta pathway."
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"This study showed that OTUD1 deubiquitinates PDE5A, leading to its stabilization and increased cGMP degradation, which exacerbates cardiac hypertrophy and heart failure 58.Our research advances the understanding of OTUD1's role in cardiac hypertrophy and remodeling by elucidating the specific molecular mechanism involving the METTL3-mediated m6A modification of OTUD1 mRNA."
OTUD1 affects Neoplasm Invasiveness
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OTUD1 inhibits Neoplasm Invasiveness.
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OTUD1 inhibits Neoplasm Invasiveness. 6 / 6
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"Moreover, more studies need to be performed to determine whether OTUD1 exerts consistent roles in mice models.In conclusion, this investigation for the first time has elucidated that OTUD1 inhibits NSCLC cell progression including cell growth, migration and invasion by stabilizing and ubiqutinating the tumor suppressor, KLF4."
OTUD1 activates Neoplasm Invasiveness.
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OTUD1 activates Neoplasm Invasiveness. 1 / 1
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OTUD1 is modified
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OTUD1 is ubiquitinated.
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"Using both the K63-specific mutant and the K63R mutant of ubiquitin, we found that of these four YAP-interacting DUBs, only OTUD1 clearly reduced K63-linked ubiquitination of YAP (Supplementary Fig. xref ), while the other three DUBs (JOSD2, OTUD7B, and YOD1) substantially reduced non-K63-linked ubiquitination of YAP (Supplementary Fig. xref )."
OTUD1 is degraded.
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OTUD1 affects signal transduction
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OTUD1 activates signal transduction. 5 / 5
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OTUD1 bound to PGAM5 activates signal transduction. 1 / 1
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OTUD1 affects inflammatory response
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OTUD1 inhibits inflammatory response.
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OTUD1 activates inflammatory response.
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"OTUD1 negatively regulates the cell cycle to inhibit the abnormal proliferation of cancer cells, since OTUD1 interacts with phosphatase and tensin homolog (PTEN), a negative regulator of the AKT (also known as protein kinase B) and NF-κB signaling pathways, and regulates its stability ( xref C)."
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"For example, OTUD1 can enhance the stability of fibrinogen-like protein 1 in liver microenvironment and thus regulate tumor progression via tumor associated macrophages-OTUD1- fibrinogen-like protein 1 axis (Li et al., 2023a); moreover, OTUD1 can serve a negative prognostic factor for hepatocellular carcinoma (Wu et al., 2019)."
OTUD1 affects Angiotensin-2
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Bisphenol A affects OTUD1
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Bisphenol A increases the amount of OTUD1.
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Bisphenol A decreases the amount of OTUD1.
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sparser
"OTUD1 negatively regulates the cell cycle to inhibit the abnormal proliferation of cancer cells, since OTUD1 interacts with phosphatase and tensin homolog (PTEN), a negative regulator of the AKT (also known as protein kinase B) and NF-κB signaling pathways, and regulates its stability ( xref C)."
OTUD1 affects type I IFNs
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OTUD1 affects cell growth
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OTUD1 inhibits cell growth. 5 / 5
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"Moreover, more studies need to be performed to determine whether OTUD1 exerts consistent roles in mice models.In conclusion, this investigation for the first time has elucidated that OTUD1 inhibits NSCLC cell progression including cell growth, migration and invasion by stabilizing and ubiqutinating the tumor suppressor, KLF4."
OTUD1 affects Heart Failure
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"Hence, we reported that the m6A-modified mRNA of OTUD1 by METTL3 was a target of YTHDF1.Next, we transfected the METTL3 plasmid and si-YTHDF1 in AC16 at the same time and demonstrated that the elevated protein expression of OTUD1 by METTL3 overexpression could be rescued by YTHDF1 silencing (Figure 3N)."
OTUD1 affects necroptotic process
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OTUD1 affects iron ion transport
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OTUD1 activates iron ion transport. 4 / 4
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"In the intestinal lamina propria, the deletion of OTUD1 will result in significantly increased numbers of DCs during dextran sulfate sodium treatment.32 Previous research has revealed that OTUD1 can promote iron transport ferroptosis via stabilizing IREB2 and thereby induce ferroptosis."
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OTUD1 affects cytokine production
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OTUD1 inhibits cytokine production.
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OTUD1 inhibits cytokine production. 2 / 2
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OTUD1 activates cytokine production.
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OTUD1 affects NSCLC
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"Moreover, more studies need to be performed to determine whether OTUD1 exerts consistent roles in mice models.In conclusion, this investigation for the first time has elucidated that OTUD1 inhibits NSCLC cell progression including cell growth, migration and invasion by stabilizing and ubiqutinating the tumor suppressor, KLF4."
OTUD1 affects ISO
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"Macrophage OTUD1 mediates ISO‐driven inflammatory responses by deubiquitinating CARD9 and increasing the combination of CARD9 and BCL10.The cellular mechanism linking CARD9 to CLRs, specifically through the Dectin‐1 signalling pathway, has been well‐documented in the context of fungal and parasitic infections."
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"Our data showed that overexpression of OTUD1 inhibited the production of IFNbeta in response to SeV infection, whereas knockdown of Smurf1 largely blocked the negative regulation of OTUD1 on IFNbeta production (XREF_FIG), indicating that Smurf1 is required for OTUD1 mediated inhibition of interferon antiviral response."
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"During infection with SeV, overexpression of OTUD1-wild type obviously lowered the activity of IFNbeta promoter, whereas overexpression of OTUD1-CH mutant completely had no effect on the IFNbeta promoter activity (XREF_FIG), suggesting that the deubiquitinase activity of OTUD1 is important for OTUD1 mediated inhibition of IFNbeta production during viral infection."
OTUD1 affects Cell Survival
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"In Ang II-challenged TCMK-1 cells, we demonstrated that OTUD1 bound to CDK9 and induced CDK9 deubiquitination: OTUD1 catalyzed K63 deubiquitination on CDK9 with its Cys320 playing a critical role, promoting CDK9 phosphorylation and activation to induce inflammatory responses and fibrosis in kidney epithelial cells."
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"In Ang II-challenged TCMK-1 cells, we demonstrated that OTUD1 bound to CDK9 and induced CDK9 deubiquitination: OTUD1 catalyzed K63 deubiquitination on CDK9 with its Cys320 playing a critical role, promoting CDK9 phosphorylation and activation to induce inflammatory responses and fibrosis in kidney epithelial cells."
Paracetamol affects OTUD1
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Hexadecanoic acid affects OTUD1
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Hexadecanoic acid increases the amount of OTUD1.
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Hexadecanoic acid decreases the amount of OTUD1.
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OTUD1 affects cell death
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OTUD1 inhibits cell death. 3 / 3
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"These results indicated that OTUD1 suppresses the NF-κB-mediated inflammatory and ROS-induced oxidative damage responses, as well as cell death through specific deubiquitination in an in vivo colitis model.To further clarify the pathophysiological role of OTUD1 in vivo, we adopted LPS/GalN-induced acute hepatitis and LPS-induced sepsis models, which are associated with inflammatory and oxidative responses [29–31]."
OTUD1 affects Vascular Remodeling
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3
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"Mechanistically, leptin treatment significantly increased the chromatin enrichment of the transcription factor c-Jun, including the OTUD1 gene enhancer, which was sufficient to increase the OTUD1 protein level and subsequently cause OTUD1 aggresome formation, ASK1 recruitment and JNK/c-Jun pathway activation."
OTUD1 affects IFNbeta promoter
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OTUD1 affects Cell Hypoxia
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OTUD1 inhibits Cell Hypoxia.
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OTUD1 activates Cell Hypoxia.
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OTUD1 activates Cell Hypoxia. 1 / 1
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OTUD1 affects Aurora-A
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Infections affects OTUD1
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Tetrachloromethane affects OTUD1
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Polyubiquitin chains affects OTUD1
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Phenylmercury acetate affects OTUD1
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Oleic acid affects OTUD1
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MiR-26a affects OTUD1
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Hsa-miR-19b-3p affects OTUD1
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Hsa-miR-181a-5p affects OTUD1
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Cyclosporin A affects OTUD1
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Benzo[a]pyrene affects OTUD1
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Benzo[a]pyrene demethylates OTUD1.
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Benzo[a]pyrene decreases the amount of OTUD1.
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OTUD1 affects regulation of cell cycle
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OTUD1 activates regulation of cell cycle. 2 / 2
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"Moreover, more studies need to be performed to determine whether OTUD1 exerts consistent roles in mice models.In conclusion, this investigation for the first time has elucidated that OTUD1 inhibits NSCLC cell progression including cell growth, migration and invasion by stabilizing and ubiqutinating the tumor suppressor, KLF4."
OTUD1 affects proteasome inhibitor
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OTUD1 affects production
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OTUD1 affects polyubiquitin chains
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OTUD1 affects pathway
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OTUD1 affects ferroptosis
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OTUD1 activates ferroptosis. 2 / 2
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"In the intestinal lamina propria, the deletion of OTUD1 will result in significantly increased numbers of DCs during dextran sulfate sodium treatment.32 Previous research has revealed that OTUD1 can promote iron transport ferroptosis via stabilizing IREB2 and thereby induce ferroptosis."
OTUD1 affects cell cycle
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OTUD1 inhibits cell cycle. 2 / 2
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"OTUD1 negatively regulates the cell cycle to inhibit the abnormal proliferation of cancer cells, since OTUD1 interacts with phosphatase and tensin homolog (PTEN), a negative regulator of the AKT (also known as protein kinase B) and NF-κB signaling pathways, and regulates its stability (Figure 2C)."
reach
"143
OTUD1 promotes the deubiquitination of IREB2, which inhibits the degradation of IREB2 protein and activates the expression of TFRC, thereby increasing the concentration of iron ions in tumor cells and enhancing the sensitivity to ferroptosis as well as the infiltration of CD8+ T cells, improving antitumor immune response."
OTUD1 affects Reactive Oxygen Species
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OTUD1 affects RIG-I-like receptors
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OTUD1 affects Pathway
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"This study showed that OTUD1 deubiquitinates PDE5A, leading to its stabilization and increased cGMP degradation, which exacerbates cardiac hypertrophy and heart failure 58.Our research advances the understanding of OTUD1's role in cardiac hypertrophy and remodeling by elucidating the specific molecular mechanism involving the METTL3-mediated m6A modification of OTUD1 mRNA."
OTUD1 affects OSCS
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OTUD1 affects K48-
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OTUD1 affects K33
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"In addition, loss of OTUD1 reduced the c-Jun phosphorylation level in SKOV3, OVCAR8 and CAOV3 cells (Supplementary Fig. 2e), implying that OTUD1 probably regulates OSCS by activating the JNK/c-Jun pathway.Moreover, depletion of OTUD1 reduced the ASK1 phosphorylation level in SKOV3 and OVCAR8 cells (Supplementary Fig. 2f)."
reach
"In addition, loss of OTUD1 reduced the c-Jun phosphorylation level in SKOV3, OVCAR8 and CAOV3 cells (Supplementary Fig. 2e), implying that OTUD1 probably regulates OSCS by activating the JNK/c-Jun pathway.Moreover, depletion of OTUD1 reduced the ASK1 phosphorylation level in SKOV3 and OVCAR8 cells (Supplementary Fig. 2f)."
OTUD1 affects Infections
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OTUD1 affects Carcinoma, Non-Small-Cell Lung
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OTUD1 affects Carcinogenesis
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OTUD1 inhibits Carcinogenesis.
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OTUD1 inhibits Carcinogenesis. 1 / 1
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OTUD1 activates Carcinogenesis.
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OTUD1 activates Carcinogenesis. 1 / 1
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OTUD1 affects ASK1-p38
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K33 affects OTUD1
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"Similar as the BRCA1 and BRCA2 tumor suppressors, expression of OTUD1 was significantly suppressed by wild-type HRAS in p53 null MCF10A cells, but not in the control MCF10A cells (p53-wt), indicating that gain of oncogenic RAS together with loss of p53 tumor suppressor could lead to decreased OTUD1 function (GSE81593)."
reach
"Consistent with the notion that activation of HRAS inhibits OTUD1 expression in p53 mutant cells, we found that upon ectopic expression of constitutively active HRASV12, OTUD1 is downregulated in p53 mutant MDA-MB-231 (both the early passage and the bone-metastatic (BM) cell lines) but not in p53 wt MCF7 cells, TGF-beta and HRAS collaborate to promote EMT, invasion and cancer stem traits in breast cancer cells 36."
sparser
"In Ang II-challenged TCMK-1 cells, we demonstrated that OTUD1 bound to CDK9 and induced CDK9 deubiquitination: OTUD1 catalyzed K63 deubiquitination on CDK9 with its Cys320 playing a critical role, promoting CDK9 phosphorylation and activation to induce inflammatory responses and fibrosis in kidney epithelial cells."
reach
"In Ang II-challenged TCMK-1 cells, we demonstrated that OTUD1 bound to CDK9 and induced CDK9 deubiquitination: OTUD1 catalyzed K63 deubiquitination on CDK9 with its Cys320 playing a critical role, promoting CDK9 phosphorylation and activation to induce inflammatory responses and fibrosis in kidney epithelial cells."
Air Pollutants affects OTUD1
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Air Pollutants increases the amount of OTUD1.
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Air Pollutants decreases the amount of OTUD1.
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Valproic acid affects OTUD1
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Thioacetamide affects OTUD1
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Testosterone affects OTUD1
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Sodium arsenite affects OTUD1
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Si-OTUD1-2 affects OTUD1
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Pirinixic acid affects OTUD1
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Phenformin affects OTUD1
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Ovarian tumor domain affects OTUD1
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Nickel sulfate affects OTUD1
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Methyltestosterone affects OTUD1
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Methyl methanesulfonate affects OTUD1
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Lipopolysaccharide affects OTUD1
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Lipopolysaccharide activates OTUD1. 1 / 1
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Indole-3-methanol affects OTUD1
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Hsa-mir-4329 affects OTUD1
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Hsa-mir-4262 affects OTUD1
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Hsa-miR-6761-5p affects OTUD1
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Hsa-miR-506-3p affects OTUD1
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Hsa-miR-3613-3p affects OTUD1
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Hsa-miR-335-5p affects OTUD1
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Hsa-miR-21-5p affects OTUD1
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Hsa-miR-181b-5p affects OTUD1
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Hsa-miR-124-3p affects OTUD1
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Dorsomorphin affects OTUD1
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Dibutyl phthalate affects OTUD1
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Coumestrol affects OTUD1
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Copper atom affects OTUD1
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Benzene-1,2,4-triol affects OTUD1
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All-trans-retinoic acid affects OTUD1
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Actinomycin D affects OTUD1
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VE-822 affects OTUD1
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Tobacco Smoke Pollution affects OTUD1
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Particulate Matter affects OTUD1
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PGAM5 affects 293T
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OTUD1 affects wound healing
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OTUD1 inhibits wound healing. 1 / 1
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OTUD1 affects type I interferon production
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OTUD1 inhibits type I interferon production. 1 / 1
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OTUD1 affects signaling
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OTUD1 affects self-ubiquitination
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eidos
"OTUD1 interacts with Smurf1 and functions as a deubiquitinase to remove the K48-linked ubiquitination of Smurf1 , prevent its self-ubiquitination degradation , and upregulate its protein level ; whereas the binding of Ndfip1 to MAVS recruits Smurf1 to MAVS , and the interaction between Ndfip1 and Smurf1 enhances the self-ubiquitination ( possibly k63-linked ) and enzyme activity of Smurf1 ( Table 1 ) ( 47 , 49 ) ."
OTUD1 affects release molecular patterns
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OTUD1 affects recruitment NF-kappaB essential modulator
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OTUD1 affects reactive oxygen species
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OTUD1 activates reactive oxygen species. 1 / 1
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OTUD1 affects protein stabilization
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OTUD1 activates protein stabilization. 1 / 1
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OTUD1 affects proteasome inhibitors
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OTUD1 affects proinflammatory cytokine
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OTUD1 affects polyubiquitination
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OTUD1 affects pathways
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OTUD1 affects navitoclax
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OTUD1 activates navitoclax. 1 / 1
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OTUD1 affects melatonin-induced Bim
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OTUD1 affects interferon-mediated disease128
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OTUD1 affects interferon IFN antiviral pathway
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OTUD1 affects homeostatic process
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OTUD1 inhibits homeostatic process. 1 / 1
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OTUD1 affects function OTUD1
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eidos
"OTUD1 ( Ovarian Tumor Family Deubiquitinase 1 , FDR = 3.74 x 10-13 ) can inhibit nuclear translocation and transcriptional activity of the IFNgamma-activated transcription factor IRF3 ( Lu et al ., 2018 ) , and loss of function of OTUD1 is associated with auto-immune diseases mediated by interferons ( Lu et al ., 2018 ) ."
OTUD1 affects cell differentiation
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OTUD1 activates cell differentiation. 1 / 1
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OTUD1 affects ccRCC
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OTUD1 affects cancer cells
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OTUD1 affects cancer cell growth
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OTUD1 affects activation
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1
reach
"For example, OTUD1 can enhance the stability of fibrinogen-like protein 1 in liver microenvironment and thus regulate tumor progression via tumor associated macrophages-OTUD1- fibrinogen-like protein 1 axis (Li et al., 2023a); moreover, OTUD1 can serve a negative prognostic factor for hepatocellular carcinoma (Wu et al., 2019)."
OTUD1 affects Smurf1-MAVS/TRAF3/TRAF6
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OTUD1 affects SCF SKP2
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OTUD1 affects Reperfusion Injury
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OTUD1 activates Reperfusion Injury. 1 / 1
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OTUD1 affects Release
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OTUD1 affects Polyubiquitin
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OTUD1 activates Polyubiquitin. 1 / 1
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"In short, OTUD1 prefers abolishing proteosome-mediated NRF2 degradation rather than modulating NRF2 function through removing K63 polyubiquitin scaffold.Due to its robust cytoprotective role in preventing oxidative stress and inflammation, NRF2 activation is considered a promising therapeutic strategy for numerous diseases characterized by oxidative stress [40]."
OTUD1 affects OSCS maintenance
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OTUD1 affects MCF10A cells expressing RAS metastasis breast cancer cells mice
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OTUD1 affects MAVS/TRAF3/TRAF6
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OTUD1 affects MAVS/TRAF3/TRAF6 signalosome
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OTUD1 affects MAVS/TRAF3/TRAF6 signalosome proteins
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OTUD1 affects MAVS/TRAF3/TRAF6 proteins
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OTUD1 affects MAVS/TRAF3/TRAF6 protein
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"Importantly, in vivo and in vitro, OTUD1 was shown to negatively regulate inflammatory responses and play a protective role in sepsis-induced pathological lung injury by mechanistically inhibiting the activation of the transforming growth factor-beta-activated kinase 1 (TAK1)-mediated mitogen-activated protein kinase (MAPK) and nuclear factor kappa-B (NF-κB) signaling pathways in the present study."
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"Importantly, in vivo and in vitro, OTUD1 was shown to negatively regulate inflammatory responses and play a protective role in sepsis-induced pathological lung injury by mechanistically inhibiting the activation of the transforming growth factor-beta-activated kinase 1 (TAK1)-mediated mitogen-activated protein kinase (MAPK) and nuclear factor kappa-B (NF-κB) signaling pathways in the present study."
OTUD1 affects KL4
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OTUD1 affects K63
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OTUD1 affects K48-linked polyubiquitination Tyk2
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OTUD1 affects Inflammatory Bowel Diseases
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OTUD1 activates Inflammatory Bowel Diseases. 1 / 1
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OTUD1 affects Inflammatory Bowel Disease
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OTUD1 inhibits Inflammatory Bowel Disease. 1 / 1
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OTUD1 affects IgL
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OTUD1 affects ISRE promoter
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OTUD1 affects IRF3/7
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OTUD1 affects IFN-I
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OTUD1 affects H9c2
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OTUD1 affects Figures 2E-F
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OTUD1 affects E3 ubiquitin ligase Smurf1
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OTUD1 affects DNA repair
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OTUD1 inhibits DNA repair. 1 / 1
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OTUD1 affects ChFP
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"OTUB2, OTUD3, USP10 and UCHL1 expression did not alter the ChFP:GFP ratio of the control reporter while OTUD1 and USP21 only modestly elevated the ChFP:GFP ratio indicating that the identified Dubs specifically alter the ability of ribosomes to progress through a poly(A)-induced ribosomal stall (Figure 3B)."
OTUD1 affects Caspase-Independent Caspase-Dependent Apoptosis
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OTUD1 affects Adenocarcinoma of Lung
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OTUD1 activates Adenocarcinoma of Lung. 1 / 1
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OTUD1 affects AHI1-mediated Tyk2
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OTUD1 affects 293T
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NSC 689534 affects OTUD1
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NF-ĸB/p65 affects OTUD1
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Lipopolysaccharides affects OTUD1
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K63 affects OTUD1
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Grape Seed Proanthocyanidins affects OTUD1
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Enterolactone affects OTUD1
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Drugs, Chinese Herbal affects OTUD1
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Dietary Fats affects OTUD1
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"CSN5 facilitates tumor growth by inhibiting the degradation of Snail241, ZEB1242, surviving243 and FOXM1244, whereas curcumin-induced CSN5 depletion decreases PD-L1 expression and enhances the anticancer efficacy of anti-CTLA4 drugs245.Tumor-suppressive DUB families, CYLD lysine 63 deubiquitinase (CYLD) in the USP family and OTU deubiquitinase 1 (OTUD1) in the OTU family, constitute the second type of DUBs."
Aurora-A affects OTUD1
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Acrylamide affects OTUD1
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ATR inhibitor affects OTUD1
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293T affects PGAM5
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2-hydroxypropanoic acid affects OTUD1
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17beta-estradiol affects OTUD1
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1,2-dichloroethane affects OTUD1
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4,4'-sulfonyldiphenol affects OTUD1
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