IndraLab

Statements

OTUD1 inhibits Neoplasm Metastasis. 11 / 11
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"Moreover, ectopic expression of OTUD1 significantly inhibited metastasis in control cells but did not show significant inhibitory effect in the SMAD7 knockout cells."
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"Relatively, OTUD1 also can inhibit tumor metastasis by preventing the degradation of SMAD family member 7 (SMDA7), which can inhibit tumor metastasis by blocking TGF-β signaling pathway (Zhang et al., 2017)."
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"Breast cancer metastasis suppressor OTUD1 deubiquitinates SMAD7."
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"Importantly, OTUD1 is lost in multiple types of human cancers and loss of OTUD1 increases metastasis in intracardial xenograft and orthotopic transplantation models, and correlates with poor prognosis among breast cancer patients."
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"Thus, OTUD1 represses breast cancer metastasis by mitigating TGF-beta-induced pro oncogenic responses via deubiquitination ofSMAD7."
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"OTUD1 inhibits metastasis in transplantable mouse models."
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"Taken together, these analyses show that loss of OTUD1 strongly promotes breast cancer lung metastasis."
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"Therefore, our studies suggest that OTUD1 inhibits lung metastasis in transplantable mouse models."
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"OTUD1 inhibits breast cancer metastasis by reducing TGF-β-induced tumor-promoting responses by deubiquitinating SMAD7 [7]."
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"Although cell transplantation induced bone metastasis to similar levels around day 21 post-injection, expression of OTUD1 wild-type (wt) beginning at day 21 significantly suppressed metastasis around day 35, which also led to increased mice survival."
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"In this model, OTUD1 represses breast cancer metastasis by mitigating TGF-β activity and loss of OTUD1 in aggressive forms derives TGF-β signaling and metastasis."
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