IndraLab

Statements

OTUD1 inhibits Neoplasm Metastasis. 8 / 8
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"Importantly, OTUD1 is lost in multiple types of human cancers and loss of OTUD1 increases metastasis in intracardial xenograft and orthotopic transplantation models, and correlates with poor prognosis among breast cancer patients."
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"Moreover, ectopic expression of OTUD1 significantly inhibited metastasis in control cells but did not show significant inhibitory effect in the SMAD7 knockout cells."
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"OTUD1 inhibits metastasis in transplantable mouse models."
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"Breast cancer metastasis suppressor OTUD1 deubiquitinates SMAD7."
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"Therefore, our studies suggest that OTUD1 inhibits lung metastasis in transplantable mouse models."
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"Although cell transplantation induced bone metastasis to similar levels around day 21 post-injection, expression of OTUD1 wild-type (wt) beginning at day 21 significantly suppressed metastasis around day 35, which also led to increased mice survival."
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"Thus, OTUD1 represses breast cancer metastasis by mitigating TGF-beta-induced pro oncogenic responses via deubiquitination ofSMAD7."
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"Taken together, these analyses show that loss of OTUD1 strongly promotes breast cancer lung metastasis."
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