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OTUD1 binds AIFM1. 4 / 4
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"Co‐IP assays showed that AIF selectively binds to the linker domain of OTUD1 (Figure S3C, Supporting Information), while OTUD1 associates with the NADH binding and Loop domains of AIF (Figure S3D, Supporting Information)."
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"We next performed in vitro pulldown assays to investigate whether OTUD1 could directly bind to AIF."
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"Among the proteins identified by MS, we focused on AIF (Figure  xref , xref ), which functions as an inducer of the caspase‐independent apoptosis pathway. [ xref ] To validate the interaction between OTUD1 and AIF, we first cotransfected Flag‐AIF and V5‐OTUD1 into 293T cells and performed immunoprecipitation using anti‐Flag magnetic beads."
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"OTUD1 Interacts with AIF and Promotes AIF Nuclear Translocation."
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