IndraLab

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OTUD1 deubiquitinates IREB2. 7 / 7
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"OTUD1 prevents ferroptosis by deubiquitinating and stabilizing IREB2."
37600367
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"Thus, targeting CD36 can reshape the composition and function of T cells in the TME through the ferroptosis pathway.The ovarian tumor domain-containing protein 1 (OTUD1) is involved in the deubiquitination of iron-responsive element-binding protein 2 (IREB2), stabilizing IREB2 to enhance iron transport mediated by transferrin receptor 1 (TFR1)."
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"OTUD1 was also shown to exacerbate colon cancer progression by deubiquitinating and stabilizing iron-responsive element-binding protein 2 (IREB2) , indicating that OTUD1 could act as an oncogene."
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"Song et al. found that overexpression of OTUD1 inhibits the ubiquitination and degradation of iron-responsive element-binding protein 2 (IREB2) in colorectal cancer cells."
38288118
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"143 OTUD1 promotes the deubiquitination of IREB2, which inhibits the degradation of IREB2 protein and activates the expression of TFRC, thereby increasing the concentration of iron ions in tumor cells and enhancing the sensitivity to ferroptosis as well as the infiltration of CD8+ T cells, improving antitumor immune response."
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"In contrast, OTUD1 is specifically down-regulated in CRC, resulting in hyperubiquitination of its downstream protein, IRP2, promoting its degradation, and reducing iron uptake by CRC cells via TfR1 ( Figure 3 ) (8).4 Genes associated with CRC."
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"OTUD1 stimulates ROS generation and ferroptosis by deubiquitinating and stabilizing IREB2 and promoting iron transportation."
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