IndraLab

Statements

OTUD1 leads to the phosphorylation of MAP3K5. 4 / 4
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"As shown in Fig. 2d, ectopic OTUD1 expression upregulated apoptosis signal-regulation kinase-1 (ASK1) and increased ASK1 phosphorylation levels."
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"Despite significant advancements in the identification of potential molecular targets and signaling pathways within the realm of cardiac hypertrophy 34-37, the existing clinical pharmacological strategies for managing this condition remain unsatisfactory.To the best of our knowledge, this is the first study to demonstrate that OTUD1 promotes pathological cardiac hypertrophy by upregulating ASK1 phosphorylation."
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"IHC analysis of xenograft tumors also revealed that OTUD1 but not OTUD1 increased ASK1 protein levels and JNK phosphorylation (Supplementary Fig. 5h)."
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"Mechanically, Otud1 directly interacts with Pgam5 and Ask1 to inhibit Pgam5 ubiquitination degradation and subsequently elevate Ask1 phosphorylation."
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