IndraLab

Statements

OTUD1 activates SMAD7. 4 / 4
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"The deubiquitinase OTUD1 was found to enable the antagonistic role of SMAD7 on TGF-beta signaling."
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"By doing so, OTUD1 enables SMAD7 function thereby antagonizing TGF-beta and SMAD signaling."
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"Ectopic expression of OTUD1-wt, but not OTUD1-CA, prolonged the half-life of endogenous SMAD7."
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"Given our results that OTUD1 enables SMAD7 and SMURF2 function, we examined whether OTUD1 misexpression can regulate TbetaRI levels at the cell surface, the location where intracellular signaling is initiated."
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