IndraLab

Statements

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"OTUD1 can activate caspase-dependent apoptosis, with interaction between C-Caspase-3 and C-Caspase-9 [ 37 ]; however, this phenomenon has only been proven in esophageal carcinoma and renal carcinoma [[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"We also found that OTUD1 directly suppresses p53 ubiquitination in cells through its catalytic activity and that OTUD1 overexpression decreases cell proliferation and increases cell apoptosis."
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"The results showed that Otud1 overexpression led to a reduction in serum ALT and AST levels (Fig. 3A), as well as a decrease in liver tissue necrosis and apoptosis induced by hepatic I/R compared to control mice (Fig. 3B and C)."
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"OTUD1 knockdown inhibited melatonin-induced Bim upregulation and apoptosis in cancer cells ."
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"Moreover, we observed that OTUD1 overexpression induced p53-dependent apoptosis and dramatically inhibited cell growth."
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"OTUD1 overexpression reduces cell proliferation and increases apoptosis [35]."
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"Melatonin induces apoptotic cell death through Bim stabilization by Sp1-mediated OTUD1 upregulation."
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"Moreover, OTUD1 overexpression promoted the cleavage of caspase-3 and PARP, which are apoptotic indicators, and increased apoptosis."
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