IndraLab

Statements

OTUD1 activates iron ion transport. 4 / 4
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"A previous study showed that OTUD1 enhances iron transport and potentiates host antitumor immunity in colon cancer ."
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"In the intestinal lamina propria, the deletion of OTUD1 will result in significantly increased numbers of DCs during dextran sulfate sodium treatment.32 Previous research has revealed that OTUD1 can promote iron transport ferroptosis via stabilizing IREB2 and thereby induce ferroptosis."
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"For example, OTUD1 has been shown to enhances iron transport and potentiate antitumor immunity in colon cancer by targeting/regulating iron-responsive element-binding protein 2 33."
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"OTUD1 promotes transferrin receptor protein 1 (TFRC)-mediated iron transport through deubiquitination and stabilization of IREB2, leading to increased ROS production and ferroptosis."
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