IndraLab

Statements

Modified OTUD1 increases the amount of SMURF1. 4 / 4
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"RNA virus infection promotes NF-kappaB-dependent expression of OTUD1 that upregulates Smurf1 protein levels."
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"In this study, we reveal that RNA virus infection activates expression of OTUD1, which in turn interacts with Smurf1 and upregulates Smurf1 protein levels by deubiquitination effects."
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"We further found that OTUD1 overexpression upregulated protein level of Smurf1, rather than Smurf2 (XREF_SUPPLEMENTARY)."
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"Overexpression of OTUD1 upregulated exogenous Smurf1 protein levels in a dose dependent manner (XREF_FIG)."
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