IndraLab

Statements

OTUD1 is ubiquitinated. 6 / 6
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"Furthermore, we analyzed ubiquitination of endogenous Smurf1 in Otud1 +/+ and Otud1 -/- MEFs."
29734366
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"The E3-ligase KEAP1 binds and ubiquitinates OTUD1."
36357400
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"This ETGE-dependent interaction was validated by co-immunoprecipitation of endogenous proteins, along with KEAP1-mediated ubiquitination of OTUD1."
39941813
sparser
"KEAP1 mediated ubiquitination of OTUD1 had no influence on its levels, so the biological role of this interaction remained unclear [ xref ]."
39941813
sparser
"As expected, OTUD1 lacking the ETGE motif was less ubiquitinated compared to the wild type form (Fig.  xref ) suggesting that OTUD1 might be a target of the KEAP1 ubiquitin ligase activity."
36357400
sparser
"Using both the K63-specific mutant and the K63R mutant of ubiquitin, we found that of these four YAP-interacting DUBs, only OTUD1 clearly reduced K63-linked ubiquitination of YAP (Supplementary Fig.  xref ), while the other three DUBs (JOSD2, OTUD7B, and YOD1) substantially reduced non-K63-linked ubiquitination of YAP (Supplementary Fig.  xref )."
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