IndraLab

Statements

OTUD1 deubiquitinates TP53. 7 / 8
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"We also found that OTUD1 directly suppresses p53 ubiquitination in cells through its catalytic activity and that OTUD1 overexpression decreases cell proliferation and increases cell apoptosis."
28216291
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"OTUD1, OTUD5 and USP11 directly deubiquitinating p53 and functional proteins were required for p53 stabilization [XREF_BIBR - XREF_BIBR]."
29142505
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"In the present study, we found that OTUD1 directly suppressed p53 ubiquitination in cells, leading to its stabilization and activation."
28216291
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"Other DUBs, OTUD1 and OTUD5, are also involved in the deubiquitination and stabilization of TP53 in response to DNA damage stress in U2OS cells [51,52]."
36551253
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"OTUD1 directly suppresses the ubiquitination of p53 in cells to increase apoptosis and decrease cell proliferation, and a previous study by Piao et al (26) indicated that OTUD1 exerted a pivotal role in regulating p53 stability and activity."
31612050
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"Our results showed that OTUD1 deubiquitinated p53 and that functional OTUD1 was required for p53 stabilization."
28216291
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"OTUD1 acts as a DUB to regulate p53 stability and directly inhibits p53 ubiquitination through its catalytic activity."
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