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OTUD1 inhibits Interferon. 10 / 10
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"] OTUD1 was also reported to inhibit IFN production during RNA virus infection ."
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"After the BVDV infection, the expression of OTUD1 is upregulated in DDIT3-overexpressing cells and inhibits IFN antiviral responses."
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"OTUD1 Negatively Regulates Type I IFN Induction by Disrupting Noncanonical Ubiquitination of IRF3."
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"Therefore, the authors concluded that the DDIT3–OTUD1–MAVS pathway suppresses IFN production through the degradation of MAVS.Patients with major depressive disorder (MDD) have a higher risk of viral infection."
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"Hence , OTUD1 cleaves the K6-linked ubiquitin chain and leads to the disassociation of IRF3 from the promoter region of target genes , thereby attenuating type I IFN induction ."
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"Furthermore, OTUD1 inhibits type 1 IFN induction after virus infection through cleaving noncanonical K6-linked ubiquitination of IRF3 [83]."
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"OTUD1 then removes the K63-linked ubiquitin chain from K98 of IRF3 and attenuates the RIG-I-like receptors (RLRs)-mediated IFN production pathway (Figure 4A)."
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"Additionally, OTUD1 downregulates the induction of type I IFN by cleaving the viral infection-induced atypical K6-linked ubiquitination of IRF3 [31]."
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"Taken together, these results suggest that both Smurf1 and the deubiquitinase activity of OTUD1 are required for the downregulation of MAVS/TRAF3/TRAF6 signalosome proteins, which results in the OTUD1 mediated inhibition of interferon antiviral response."
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"The aforementioned results prove that Smurf1 is important for OTUD1 mediated inhibition of interferon antiviral response."
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