IndraLab

Statements

OTUD1 inhibits Interferon. 7 / 7
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"Hence , OTUD1 cleaves the K6-linked ubiquitin chain and leads to the disassociation of IRF3 from the promoter region of target genes , thereby attenuating type I IFN induction ."
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"Furthermore, OTUD1 inhibits type 1 IFN induction after virus infection through cleaving noncanonical K6-linked ubiquitination of IRF3 [83]."
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"OTUD1 negatively regulates the canonical NF-κB activation, apoptosis, and necroptosis, whereas OTUD1 upregulates the interferon (IFN) antiviral pathway."
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"The aforementioned results prove that Smurf1 is important for OTUD1 mediated inhibition of interferon antiviral response."
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"OTUD1 Negatively Regulates Type I IFN Induction by Disrupting Noncanonical Ubiquitination of IRF3."
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"Taken together, these results suggest that both Smurf1 and the deubiquitinase activity of OTUD1 are required for the downregulation of MAVS/TRAF3/TRAF6 signalosome proteins, which results in the OTUD1 mediated inhibition of interferon antiviral response."
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"] OTUD1 was also reported to inhibit IFN production during RNA virus infection ."
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