IndraLab

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OTUD1 activates ferroptosis. 2 / 2
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"In the intestinal lamina propria, the deletion of OTUD1 will result in significantly increased numbers of DCs during dextran sulfate sodium treatment.32 Previous research has revealed that OTUD1 can promote iron transport ferroptosis via stabilizing IREB2 and thereby induce ferroptosis."
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"Therefore, high expression of OTUD1 promotes ferroptosis in colon cancer cells via the OTUD1-IREB2-TFR1 signaling axis, while also enhancing the cytotoxic effects of T cells."
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