IndraLab

Statements

OTUD1 binds YAP1. 10 / 10
4 | 1 5
sparser
"OTUD1 binds to YAP and removes its K63-ubiquitin chain in a Hippo-independent manner, indicating that OTUD1 is a negative regulator of YAP signaling."
36829909
reach
"OTUD1 binds to YAP and removes its K63-ubiquitin chain in a Hippo-independent manner, indicating that OTUD1 is a negative regulator of YAP signaling."
36829909
biogrid
No evidence text available
29891922
biogrid
No evidence text available
29891922
biogrid
No evidence text available
29891922
biogrid
No evidence text available
29891922
sparser
"OTUD1 binds YAP and reverses its K63 ubiquitination."
29891922
sparser
"This non-proteolytic ubiquitination can be reversed by the binding and interaction between deubiquitinase OTUD1 and YAP1; OTUD1 decreases YAP1 stability, and attenuates the cell proliferation and tumor-growth activity of YAP1 ( xref )."
32390875
sparser
"We further validated the interaction between OTUD1 and YAP in vivo and in vitro."
29891922
sparser
"Moreover, His-YAP protein purified from bacteria could be pulled down by GST-OTUD1, but not by GST, in an in vitro binding assay (Fig.  xref ), suggesting that OTUD1 directly interacts with YAP."
29891922