IndraLab

Statements

OTUD1 increases the amount of TYK2. 3 / 3
| 3
reach
"Importantly, OTUD1 knockdown inhibited the AHI1-mediated upregulation of Tyk2 levels (Fig. 4e), suggesting that OTUD1 is essential for the AHI1-mediated regulation of Tyk2 protein levels."
35821088
reach
"Importantly, AHI1 deficiency inhibited OTUD1-mediated both downregulation of Tyk2 ubiquitination (Fig. 5c) and upregulation of Tyk2 protein levels (Supplementary information, Fig. S5g), suggesting that OTUD1 regulates Tyk2 ubiquitination and protein levels dependently on AHI1.OTUD1 has been reported to be able to regulate both K48-linked and K63-linked ubiquitination of protein substrates."
35821088
reach
"We found that OTUD1 overexpression increased Tyk2 protein levels in a dose-dependent manner (Supplementary information, Fig. S5b), while OTUD1 knockout in primary macrophages dramatically reduced Tyk2 protein levels (Fig. 4d)."
35821088