IndraLab

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"Studies have shown that in colon cancer, OTUD1 can bind and promote the deubiquitination modification of IREB2 (iron-responsive element-binding protein2), a primary regulator of iron metabolism."

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"Song et al. showed that OTUD1 binds IREB2 through the N-terminal APGR, and deubiquitinates K48- and K63-linked ubiquitin chains from IREB2."