IndraLab

Statements

OTUD1 activates inflammatory response. 3 / 3
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"Intriguingly, we provided direct evidence that OTUD1 interacted with RIP2 and cleaved its K63-linked polyubiquitin chains, rather than the K48-linked chains, which led to suppression of the RIP2-induced inflammatory response."
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"Myeloid-specific OTUD1 deletion also attenuated ISO-induced murine cardiac inflammation and remodelling."
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"Taken together, our findings suggested that targeting the OTUD1‐CARD9 axis has a protective effect against ISO‐driven cardiac inflammation and HF.Inflammation participates in the progression of ISO‐induced HF."
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