IndraLab

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Infections increases the amount of OTUD1. 3 / 3
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"In addition, Sendai virus (SeV) infection promotes the deubiquitinase OTUD1 expression followed by upregulating protein levels of Smurf1 to degrade MAVS, and Smurf1 proteins interact with the MAVS/TRAF3/TRAF6 signalosome in cells infected with SeV for 8 h (48)."
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"Indeed, it was shown that infection with RNA viruses stimulates the expression of the enzyme OTU deubiquitinase1 (OTUD1), which interacts with Smurf1 and increases its intracellular expression in HEK293 lineage cells (83)."
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"In a somewhat controversial report, Zhang et al. show that OTUD1 expression is upregulated by both SeV and HSV infections, and Otud1-deficiency enhances the antiviral innate immune response and exhibits resistance against SeV and HSV infection [38]."
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