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OTUD1 inhibits RIG-I-like receptors. 2 / 2

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"Under inflammatory conditions, inducible OTUD1 acts as an immune checkpoint and blocks RIG-I-like receptors signaling."

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"OTUD1 then removes the K63-linked ubiquitin chain from K98 of IRF3 and attenuates the RIG-I-like receptors (RLRs)-mediated IFN production pathway (Figure 4A)."

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IndraLab

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OTUD1 inhibits RIG-I-like receptors. 2 / 2

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