IndraLab

Statements

OTUD1 inhibits AKT. 4 / 4
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"Moreover, analysis of OTUD1 RNA-seq data indicated that OTUD1 inhibition triggers the AKT and NF-kappa B pathways in renal cancer cells."
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"The deubiquitinase OTUD1 noncanonically suppresses Akt activation through its N-terminal intrinsically disordered region."
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"The OTUD1 C-terminal deubiquitinase domain decreased Akt K63-linked polyubiquitination, thereby coordinating the inhibitory effect of the N-terminus."
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"OTUD1 stabilizes PTEN to inhibit the PI3K/AKT and TNF-alpha/NF-kappaB signaling pathways and sensitize ccRCC to TKIs."
35280681