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OTUD1 activates Ig. 3 / 3
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"Moreover, a vast majority of OTUD1-associated proteins in our proteomic analysis belonged to ribosome or translation machinery (Supplementary Data 2) suggesting OTUD1 could mediate translation of Ig mRNA."
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"To unveil the mechanism of how OTUD1 potentiates Ig production, we performed a proximity labeling assay in cells with dox-inducible expression of OTUD1 fused to the newest generation of the biotin ligase BirA (TurboID) (Supplementary Fig. 4a)."
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"OTUD1 mediates Ig production and PI sensitivity through PRDX4."
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