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OTUD1 activates TP53. 4 / 5
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"Therefore, further research is necessary to obtain these answers.This study is the mechanism underlying OTUD1-mediated p53 stability."
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"These results indicate that the C320 residue is essential for maintaining the catalytic activity of OTUD1 and for regulating p53 stability.Next, we examined whether OTUD1 induced p53-dependent cell cy[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Moreover, we observed that OTUD1 overexpression induced p53-dependent apoptosis and dramatically inhibited cell growth."
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"Therefore, further studies are necessary to elucidate how the UIM acts OTUD1-mediated p53 deubiquitination.One important finding of the present study is the mechanism underlying OTUD1-mediated p53 reg[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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