IndraLab

Statements

OTUD1 binds BST2. 8 / 8
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sparser
"In addition, in this study, we only used labeled proteins to verify the interaction between OTUD1 and BST-2, and did not verify endogenous protein interaction or deeply explore the relationship between OTUD1, BST-2 and Vpu."
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sparser
"While this mutation did not disrupt the interaction between OTUD1 and BST-2 ( xref D), it abolished the ability of OTUD1 to reduce BST-2 ubiquitination ( xref E,F)."
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sparser
"In this study, we conducted a small interfering RNA (siRNA) screening of human DUBs and determined that OTUD1 interacts with BST-2, leading to a reduction in its K48- and K63-linked ubiquitination."
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reach
"While this mutation did not disrupt the interaction between OTUD1 and BST-2 (Figure 4D), it abolished the ability of OTUD1 to reduce BST-2 ubiquitination (Figure 4E,F)."
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reach
"In addition, in this study, we only used labeled proteins to verify the interaction between OTUD1 and BST-2, and did not verify endogenous protein interaction or deeply explore the relationship between OTUD1, BST-2 and Vpu."
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sparser
"Notably, OTUD1 interacts with BST-2, reducing its K48- and K63-linked ubiquitination at Lys21, thereby stabilizing its surface expression."
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sparser
"Co-immunoprecipitation showed that OTUD1 may interact with BST-2 protein ( xref A,B)."
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sparser
"Collectively, these findings indicate that OTUD1 not only interacts with BST-2, but also plays a crucial role in regulating BST-2 protein levels."
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