IndraLab

Statements

reach
"In this process, OTUD1 preferentially removes the K48-linked ubiquitin chain over the K63 chain, and the OTUD1-mediated cell cycle arrest then leads to apoptosis (Figure 2A)."
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"Moreover, more studies need to be performed to determine whether OTUD1 exerts consistent roles in mice models.In conclusion, this investigation for the first time has elucidated that OTUD1 inhibits NSCLC cell progression including cell growth, migration and invasion by stabilizing and ubiqutinating the tumor suppressor, KLF4."
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