IndraLab

Statements

reach
"From our screen, we have identified that loss of OTUD1 enables breast cancer cells to undergo EMT and gain cancer stem cell traits thereby driving metastatic spread to distant organs, such as bone and lung."
29235476
reach
"Combined, the in vitro and in vivo evidence in this study elucidates critical functions of OTUD1 in the termination of TGF-beta and SMAD-induced metastatic activation, indicating that OTUD1 restricts the EMT and cancer stem cell traits during metastasis."
29235476
reach
"OTUD1 causes suppression of TGF-beta downstream signals and EMT."
29235476
eidos
"Moreover , OTUD1 suppresses TGF-beta signaling and EMT in MCF10A cells expressing RAS and metastasis of breast cancer cells in mice , respectively , presumably through deubiquitylating SMAD7 thus enabling SMURF2 binding and subsequent TGFR turnover43 ."
30696809