IndraLab

Statements

OTUD1 binds CARD9. 19 / 19
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"The interaction of OTUD1 and CARD9 was confirmed in HEK‐293T, heart tissues and MPMs isolated from WT mice, respectively (Figure 5D–F)."
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"What's more, ISO stimulation increased OTUD1‐CARD9 complex formation in heart tissues and MPMs (Figure 5E,F)."
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"OTUD1 directly interacted with CARD9 and cleaved polyubiquitin chains from CARD9, leading to the activation of the canonical NF-κB and MAPK pathway."
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"OTUD1 interacts with CARD9 through the OTU + UIM domain and deubiquitinates CARD9 [ xref ] ( xref C)."
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"We further demonstrated that OTUD1 directly binds to the CARD9 and then removes the K33‐linked ubiquitin from CARD9 to promote the assembly of the CARD9‐BCL10‐MALT1 (CBM) complex, without affecting CARD9 stability."
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"These results suggested that the OTUD1‐CARD9 axis is a new pro‐inflammatory signal in ISO‐challenged macrophages and targeting this axis has a protective effect against ISO‐induced HF."
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"This paper identified the OTUD1‐CARD9 axis in macrophages as a newly identified modulator of ISO‐stimulated cardiac remodelling."
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"The interaction of OTUD1 and CARD9 was confirmed in HEK‐293T, heart tissues and MPMs isolated from WT mice, respectively (Figure  xref )."
39118286
sparser
"What's more, ISO stimulation increased OTUD1‐CARD9 complex formation in heart tissues and MPMs (Figure  xref )."
39118286
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"OTUD1 directly interacts with CARD9 and cleaves polyubiquitin chains off CARD9."
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"Taken together, our findings suggested that targeting the OTUD1‐CARD9 axis has a protective effect against ISO‐driven cardiac inflammation and HF."
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"OTUD1 interacts with CARD9 through the OTU + UIM domain and deubiquitinates CARD9 [44] (Figure 4C)."
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"In summary, we have demonstrated that the macrophage OTUD1‐CARD9 axis mediates ISO‐induced inflammatory response, subsequently contributing to heart remodelling."
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"These evidence highlighted the OTUD1‐CARD9 axis in ISO‐driven HF and suggested that targeting OTUD1 or CARD9 could have therapeutic potential for this condition."
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"We also found that the deubiquitinase OTUD1 directly interacts with CARD9 and cleaved polyubiquitin chains from CARD9, leading to the activation of the canonical NF-κB and MAPK pathways."
38166150
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No evidence text available
33789983
reach
"OTUD1 directly interacted with CARD9 and cleaved polyubiquitin chains from CARD9, leading to the activation of the canonical NF-kappaB and MAPK pathway."
33789983
biogrid
No evidence text available
33789983
biogrid
No evidence text available
33789983