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"In line with this, OTUD1 deficiency in both primary macrophages (Fig. 5b) and MEFs (Supplementary information, Fig. S5d), as well as A549 cells (Supplementary information, Fig. S5e), markedly improved Tyk2 ubiquitination levels, whereas OTUD1 overexpression inhibited Tyk2 ubiquitination (Fig. 5c; Supplementary information, Fig. S5f)."