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OTUD1 activates OSCS. 2 / 2
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"Taken together, these results strongly suggest that OTUD1 may act as a proto-oncogene in ovarian cancer and potentiate OSCS maintenance."
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"ASK1/JNK inhibitors very effectively suppressed OSCS induced by OTUD1 overexpression (Fig. 6), and ibrutinib, an FDA-approved MKK7 inhibitor, preferentially reduced the tumorigenicity of OTUD1 ovarian cancer cells (Fig. 7)."
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