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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

OTUD1 activates TYK2. 1 / 1

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"It will be interesting to clarify the signaling crosstalk between different types of cells stimulated by different hormones in the future.In summary, we found that depression-elevated AVP induces AHI1 reduction in macrophages, which further disrupts the deubiquitinase OTUD1-mediated stabilization of cellular Tyk2, thus attenuating basal IFN-I signaling and host antiviral immune defense (Fig. 8h)."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...