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OTUD1 deubiquitinates PDE5A. 2 / 2
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"In conclusion, OTUD1 promotes heart failure by deubiquitinating and stabilizing PDE5A in cardiomyocytes."
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"This study showed that OTUD1 deubiquitinates PDE5A, leading to its stabilization and increased cGMP degradation, which exacerbates cardiac hypertrophy and heart failure 58.Our research advances the understanding of OTUD1's role in cardiac hypertrophy and remodeling by elucidating the specific molecular mechanism involving the METTL3-mediated m6A modification of OTUD1 mRNA."
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