IndraLab

Statements

OTUD1 leads to the ubiquitination of BST2. 3 / 3
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"We found that OTUD1 overexpression in HEK293T cells led to a significant reduction in BST-2 ubiquitination (Figure 4B), while OTUD1 knockdown resulted in increased ubiquitination levels (Figure 4C)."
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"To explore how OTUD1 modulates polyubiquitination of BST-2, the effects of OTUD1 on specific ubiquitin linkages were examined."
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"Interestingly, the mutation of lysine 21 completely abolished the reduction in BST-2 ubiquitination mediated by OTUD1 in HEK293T cells (Figure 5C), a finding replicated in HEK293T cells (Figure 5D)."
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