IndraLab

Statements

OTUD1 inhibits IRF3. 4 / 4
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"OTUD1 can inhibit the transcriptome activity of IRF3, thus maintaining immune homeostasis in cells and hence dose OTUD3, PTUD4, and A20 (16, 24–26)."
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"In both RNA and DNA virus infections, OTUD1 inhibits IRF3-dependent type I IFN production [ 22 ]."
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"In VSV-infected cells, OTUD1 prevented the binding of IRF3 to the promotor region of type IFN I genes by cleaving K6-linked ubiquitin chains from IRF3."
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"OTUD1 reportedly restricts IRF3 by removing its critical K6-linked ubiquitin chain from K105 (Figure 4A)."
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