IndraLab

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OTUD1 inhibits type I IFNs. 4 / 4
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"Consequently, OTUD1 negatively regulates RNA virus triggered production of type I IFNs and proinflammatory cytokines."
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"However, we noticed that OTUD1 overexpression gradually downregulated the levels of MAVS, TRAF3, and TRAF6 (XREF_FIG), which is consistent with the observation that OTUD1 overexpression inhibits the induction of type I IFNs and proinflammatory cytokines."
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"In the present study, we report that the OTU deubiquitinase 1 (OTUD1) negatively regulates RNA virus triggered production of type I IFNs and proinflammatory cytokines."
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"In a screen of deubiquitinases expression cloning library [XREF_BIBR, XREF_BIBR], we found that the deubiquitinase OTUD1 could inhibit RNA virus induced production of type I IFNs."
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