IndraLab

Statements

OTUD1 increases the amount of SMURF1. 4 / 4
| 4
reach
"For example, OTUD1 upregulates the protein levels of intracellular Smurf1 by removing the K48-linked polyubiquitin chains of Smurf1, and RNA virus infection promotes the binding of Smurf1 to MAVS, TRAF3, and TRAF6, which leads to ubiquitination-dependent degradation of the three proteins and subsequent potent inhibition of IFNs production (64)."
34707613
reach
"And OTUD1 upregulates Smurf1 protein levels by removing ubiquitination of Smurf1."
29734366
reach
"Thus, these data demonstrate that OTUD1 positively regulates cellular levels of Smurf1 by deubiquitination effects."
29734366
reach
"Furthermore, OTUD1 upregulates protein levels of intracellular Smurf1 by removing Smurf1 ubiquitination."
29734366