IndraLab

Statements

OTUD1 increases the amount of SMURF1. 6 / 6
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"Thus, these data demonstrate that OTUD1 positively regulates cellular levels of Smurf1 by deubiquitination effects."
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"The specific mechanism is: DDIT3 expression induces the production of OTUD1, which promotes the upregulation of Smurf1 expression by deubiquitinating Smurf1, and Smurf1 as E3 will degrade MAVS in a ubiquitin-dependent manner to inhibit IFN-I signaling (194)."
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"During RNA virus infection, OTUD1 is induced through the NF-κB pathway, and OTUD1 deubiquitinates Smurf1 to up-regulate the protein level of Smurf1 in cells."
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"For example, OTUD1 upregulates the protein levels of intracellular Smurf1 by removing the K48-linked polyubiquitin chains of Smurf1, and RNA virus infection promotes the binding of Smurf1 to MAVS, TRAF3, and TRAF6, which leads to ubiquitination-dependent degradation of the three proteins and subsequent potent inhibition of IFNs production (64)."
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"Furthermore, OTUD1 upregulates protein levels of intracellular Smurf1 by removing Smurf1 ubiquitination."
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"And OTUD1 upregulates Smurf1 protein levels by removing ubiquitination of Smurf1."
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