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NFE2L2 activates OTUD1. 3 / 3
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"Our findings revealed that Nrf2 depletion abrogated the suppressive effect of Otud1 on apoptosis in H/R-treated primary hepatocytes (Fig. 4I and J)."
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"Nrf2 silence also nullified Otud1 activity in upregulating Ho-1 and Nqo1 proteins (Fig. S7B), as well as in downregulating ROS production under H/R treatment (Fig. S7C)."
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"In other words, NRF2 acts as a direct substrate of OTUD1 to mediate the anti-inflammatory and antioxidant effect of OTUD1 in hepatic I/R injury."
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