IndraLab

Statements


| 2 8

sparser
"The immunoprecipitation was used to determine the interaction between OTUD1 and MCL1."

sparser
"Next, we tested whether OTUD1 interacts with MCL1."

reach
"The immunoprecipitation was used to determine the interaction between OTUD1 and MCL1."

sparser
"These results indicate that OTUD1 interacts with MCL1 and regulates its stability through deubiquitination."

sparser
"Since OTUD1 interacts with MCL1 and its enzymatic activity is required for MCL1 stability, then we tested whether OTUD1 influences the ubiquitination of MCL1."

sparser
"We also found that OTUD1 interacted with MCL1 and removed the ubiquitin chain from it."

sparser
"As shown in Fig.  xref a, Additional file xref : Fig. S3A, B, and S3B, OTUD1 interacts with MCL1 in both directions when co-transfected into cells."

sparser
"OTUD1 interacts with MCL1 and promotes MCL1 deubiquitination."

reach
"OTUD1 interacts with MCL1 and promotes its deubiquitination."

sparser
"OTUD1 interacts with MCL1 and promotes its deubiquitination."