IndraLab

Statements

OTUD1 activates Heart Failure. 5 / 5
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"OTUD1 promotes pathological cardiac remodeling and heart failure by targeting STAT3 in cardiomyocytes."
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"The first study demonstrated that OTUD1 promotes pathological cardiac remodeling and heart failure by targeting STAT3 in cardiomyocytes."
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"In addition, OTUD1 and USP15 appear to modulate cardiac myocyte remodeling in the context of heart failure, the former by targeting STAT3 [137,138]."
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"First, OTUD1 upregulation in human heart failure samples was detected from public single-cell sequencing data rather than clinically acquired data."
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"These evidence highlighted the OTUD1‐CARD9 axis in ISO‐driven HF and suggested that targeting OTUD1 or CARD9 could have therapeutic potential for this condition."
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