IndraLab

Statements

OTUD1 inhibits cell population proliferation. 10 / 10
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"OTUD1 overexpression inhibits NSCLC cell proliferation, migration and invasion."
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"Our results indicated that upregulation of OTUD1 expression inhibits TNBC cell proliferation and enhances its sensitivity to doxorubicin."
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"We also found that OTUD1 directly suppresses p53 ubiquitination in cells through its catalytic activity and that OTUD1 overexpression decreases cell proliferation and increases cell apoptosis."
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"Taken together, these results suggested that overexpression OTUD1 notably inhibits NSCLC cell progression including proliferation, migration and invasion."
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"These results suggest that OTUD1 inhibits cell proliferation by regulating cell cycle and apoptosis.p53 is a master transcription factor that performs critical regulatory functions in cells."
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"OTUD1 knockdown promotes NSCLC cell proliferation, migration and invasion."
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"OTUD1 overexpression reduces cell proliferation and increases apoptosis [35]."
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"OTUD1 negatively regulates the cell cycle to inhibit the abnormal proliferation of cancer cells, since OTUD1 interacts with phosphatase and tensin homolog (PTEN), a negative regulator of the AKT (also known as protein kinase B) and NF-κB signaling pathways, and regulates its stability (Figure 2C)."
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"Depletion of endogenous OTUD1 potentiated the capacity of RAS transformed MCF10A cells to form tumor organoids in 3D Matrigel but did not inhibit tumor cell survival and proliferation under standard 2D culture conditions."
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"OTUD1 inhibited proliferation and migration of lung cancer cells in vitro."
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