IndraLab

Statements


OTUD1 activates JNK. 3 / 3
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"Mechanistically, leptin treatment significantly increased the chromatin enrichment of the transcription factor c-Jun, including the OTUD1 gene enhancer, which was sufficient to increase the OTUD1 protein level and subsequently cause OTUD1 aggresome formation, ASK1 recruitment and JNK/c-Jun pathway activation."

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"OTUD1 activates the ASK1-p38/JNK pathways during cardiac hypertrophy."

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"These results demonstrate that OTUD1 activates the ASK1-p38/JNK signaling pathway in response to pro-hypertrophy stimulation."