IndraLab

Statements

OTUD1 activates MAVS. 3 / 3
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"Therefore, we tried to analyze whether Smurf1 could be required for OTUD1 mediated downregulation of MAVS."
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"Our data showed that knockdown of Smurf1 significantly inhibited OTUD1 mediated MAVS downregulation (XREF_FIG)."
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"Among them, OTUD4 is induced in an IRF3/7-dependent manner, and OTUD1 increases the stability of MAVS during viral infection by directly removing the K48-linked ubiquitination of MAVS, thereby promoting RLR-mediated innate immune signals (132)."
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