IndraLab

Statements

OTUD1 activates MAP3K5. 4 / 4
| 4
reach
"These results prompted us to investigate whether OTUD1 is sufficient to activate ASK1 downstream signaling and whether its deubiquitinase activity is needed for this regulation."
38351029
reach
"OTUD1 promotes ASK1 stability in a largely deubiquitinase-independent manner."
38351029
reach
"OTUD1 promotes Cardiac Hypertrophy in an ASK1-Dependent Manner."
39309432
reach
"All the above results demonstrated that OTUD1-based aggresomes contribute to ASK1 protein stabilization and persistent ASK1/JNK activation and that this function is mediated by a region (aa 105–164) located in the OTUD1 N-terminal intrinsically disordered region."
38351029