IndraLab

Statements

OTUD1 increases the amount of PRDX4. 3 / 3
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"Elucidation of how OTUD1 and PRDX4 are linked to protein synthesis will require further research.Interestingly, OTUD1 binds and selectively promotes PRDX4 levels leaving other components of the ER folding machinery intact."
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"Moreover, OTUD1 oe led to a higher amount of FL PRDX4 but not Δ1-38 PRDX4 in the ER fractions (Supplementary Fig. 5c, d), further suggesting that OTUD1 protects PRDX4 from ERAD.A previous study described OTUD2 (YOD1), a close homolog of OTUD1, as a non-selective regulator of protein retrotranslocation from ER."
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"Together these results support the model where OTUD1 increases PRDX4 protein amount which promote the formation of new IgL molecules by enforcing translation elongation."
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