IndraLab

Statements

OTUD1 activates KLF4. 3 / 3
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"Nevertheless, knockdown of OTUD1 dramatically reduced the KLF4 half‐lives (Figure 5c,d), which suggested that OTUD1 reduced the degradation of KL4."
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"The results illustrated that OTUD1 overexpression increased KLF4 protein levels while OTUD1 knockdown remarkably decreased the protein load of KLF4."
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"However, OTUD1 did not significantly affect KLF4 mRNA expression in PC9 cells (Figure 4c,d), implying that OTUD1 might mediate the post‐translational modification of KLF4."
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