IndraLab

Statements

OTUD1 deubiquitinates SMAD7. 7 / 8
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"Further investigation reveals that OTUD1 directly deubiquitinates the TGF-beta pathway inhibitor SMAD7 and prevents its degradation."
29235476
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"To demonstrate that OTUD1 can directly deubiquitinate SMAD7, we performed in vitro deubiquitination assays."
29235476
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"This confirms that OTUD1 deubiquitinates SMAD7 in vitro."
29235476
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"OTUD1 deubiquitinates SMAD7 and sustains SMAD7 stability."
29235476
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"OTUD1 can deubiquitinate SMAD7 to enable SMURF2 binding and subsequent TβRI turnover on the cell surface to increase breast cancer metastasis ."
38351029
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"OTUD1 deubiquitinates the TGF-β inhibitor SMAD7 and inhibits p53, thereby increasing the cleavage of caspase-3 and PARP-dependent apoptosis and enhancing tumor suppression248 249.Context-dependent DUBs, such as OTUD3 and USP10, constitute the third type of DUBs that exhibit contradictory functions in various tumors."
37969742
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"In breast cancer cells, OTUD1 deubiquitinates TGF-β1 inhibitor SMAD7 and increases TGFB receptor 1 turnover 46."
37153745