IndraLab

Statements

OTUD1 deubiquitinates SMAD7. 8 / 8
1 | 7
ubibrowser
"Breast cancer metastasis suppressor <span class="match term0">OTUD1</span> deubiquitinates <span class="match term1">SMAD7</span>"
29235476
reach
"Further investigation reveals that OTUD1 directly deubiquitinates the TGF-beta pathway inhibitor SMAD7 and prevents its degradation."
29235476
reach
"To demonstrate that OTUD1 can directly deubiquitinate SMAD7, we performed in vitro deubiquitination assays."
29235476
reach
"This confirms that OTUD1 deubiquitinates SMAD7 in vitro."
29235476
reach
"OTUD1 deubiquitinates SMAD7 and sustains SMAD7 stability."
29235476
reach
"OTUD1 can deubiquitinate SMAD7 to enable SMURF2 binding and subsequent TβRI turnover on the cell surface to increase breast cancer metastasis ."
38351029
reach
"OTUD1 deubiquitinates the TGF-β inhibitor SMAD7 and inhibits p53, thereby increasing the cleavage of caspase-3 and PARP-dependent apoptosis and enhancing tumor suppression248 249.Context-dependent DUBs, such as OTUD3 and USP10, constitute the third type of DUBs that exhibit contradictory functions in various tumors."
37969742
reach
"In breast cancer cells, OTUD1 deubiquitinates TGF-β1 inhibitor SMAD7 and increases TGFB receptor 1 turnover 46."
37153745