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Statements

OTUD1 binds MAP3K5. 11 / 11
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sparser
"Then, we proceeded to investigate the in vivo function of the Otud1-Ask1 axis."
39309432
sparser
"OTUD1 physically interacts with ASK1 and is involved in MAPK pathway regulation, which is essential for the maintenance of CSC properties (Fig.  xref )."
38351029
sparser
"We then examined the interaction between OTUD1 and ASK1."
38351029
sparser
"Reciprocal coimmunoprecipitation (Co-IP) revealed that OTUD1 binds to ASK1 (Fig.  xref ), and their interaction was not influenced by the enzymatically inactive OTUD1 C320A mutant (Fig.  xref )."
38351029
sparser
"As shown in Fig.  xref h, both the N-terminus and C-terminus of OTUD1 bound to ASK1."
38351029
reach
"We then examined the interaction between OTUD1 and ASK1."
38351029
reach
"Reciprocal coimmunoprecipitation (Co-IP) revealed that OTUD1 binds to ASK1 (Fig. 2e), and their interaction was not influenced by the enzymatically inactive OTUD1 C320A mutant (Fig. 2f)."
38351029
sparser
"OTUD1 is involved in MAPK/JNK pathway regulation and physically interacts with ASK1."
38351029
reach
"Because OTUD1 strongly bound to ASK1, we sought to determine whether ASK1 could be recruited to OTUD1-based aggresomes."
38351029
reach
"As shown in Fig. 2g, h, both the N-terminus and C-terminus of OTUD1 bound to ASK1."
38351029
sparser
"Because OTUD1 strongly bound to ASK1, we sought to determine whether ASK1 could be recruited to OTUD1-based aggresomes."
38351029