IndraLab

Statements

OTUD1 inhibits NSCLC. 4 / 4
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"Overexpression of OTUD1 inhibited NSCLC cell progression and it was promoted by knockdown of OTUD1."
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"OTUD1 knockdown promotes NSCLC cell proliferation, migration and invasion."
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"Our study revealed that OTUD1 suppresses NSCLC progression by mediating KLF4 stabilization, which suggests a potential gene target for the future treatment of NSCLC."
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"Moreover, more studies need to be performed to determine whether OTUD1 exerts consistent roles in mice models.In conclusion, this investigation for the first time has elucidated that OTUD1 inhibits NSCLC cell progression including cell growth, migration and invasion by stabilizing and ubiqutinating the tumor suppressor, KLF4."
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