IndraLab

Statements

OTUD1 activates Fibrosis. 8 / 8
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"Similarly, Picro Sirius Red and Masson's Trichrome staining revealed that OTUD1 knockout mice have reduced fibrosis compared to wildtype mice (Figure 2J-K, Figure S2G-L)."
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"OTUD1 deficiency prevents TAC-induced myocardial hypertrophy and fibrosis."
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"these results confirm that OTUD1 deficiency suppresses deleterious myocardial hypertrophy and fibrosis."
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"Otud1 knockout significantly ameliorated Ang II-induced HRD, whereas OTUD1 overexpression exacerbated Ang II-induced kidney damage and fibrosis."
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"OTUD1 and USP22 have been shown to promote fibrosis and injury in renal tubular epithelial cells ."
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"Our group has recently found that cardiomyocyte OTUD1 promoted angiotensin II‐ and TAC‐driven cardiac dysfunction, hypertrophy and fibrosis, while the role of OTUD1 was evaluated using the whole‐body OTUD1 knockout mice but not the myocardial‐specific OTUD1 knockout mice or BMT."
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"OTUD1 increases Ang II-induced cardiomyocyte myocardial hypertrophy and fibrosis by regulating STAT3."
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"The macrophage inflammation mediated by the ISO‐OTUD1‐CARD9 axis further promotes hypertrophy and fibrosis in cardiomyocytes and fibroblasts, respectively, inducing cardiac remodelling."
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