IndraLab

Statements

SMURF1 binds OTUD1. 9 / 12
3 | 3 6
sparser
"We found that Smurf1 was able to interact with OTUD1 ( xref )."
29734366
reach
"RNA virus infection promotes the interaction between OTUD1 and Smurf1, and binding of Smurf1 to MAVS/TRAF3/TRAF6."
29734366
reach
"Given that RNA viruses activate OTUD1 expression and subsequent Smurf1 upregulation, we further analyze whether OTUD1 interacts with Smurf1, and how Smurf1 is able to affect MAVS/TRAF3/TRAF6 proteins during RNA virus infection."
29734366
sparser
"In this study, we reveal that RNA virus infection activates expression of OTUD1, which in turn interacts with Smurf1 and upregulates Smurf1 protein levels by deubiquitination effects."
29734366
sparser
"OTUD1 interacts with Smurf1 and functions as a deubiquitinase to remove the K48-linked ubiquitination of Smurf1, prevent its self-ubiquitination degradation, and upregulate its protein level; whereas the binding of Ndfip1 to MAVS recruits Smurf1 to MAVS, and the interaction between Ndfip1 and Smurf1 enhances the self-ubiquitination (possibly k63-linked) and enzyme activity of Smurf1 ( xref ) ( xref , xref )."
32536927
reach
"We found that SeV infection promoted interaction between OTUD1 and Smurf1 (XREF_FIG)."
29734366
sparser
"RNA virus infection promotes the interaction between OTUD1 and Smurf1, and binding of Smurf1 to MAVS/TRAF3/TRAF6."
29734366
sparser
"Given that RNA viruses activate OTUD1 expression and subsequent Smurf1 upregulation, we further analyze whether OTUD1 interacts with Smurf1, and how Smurf1 is able to affect MAVS/TRAF3/TRAF6 proteins during RNA virus infection."
29734366
sparser
"Furthermore, OTUD1 regulates the ubiquitination and protein level of a HECT-type E3, Smurf1, and the OTUD1–Smurf1 axis destabilizes MAVS/TRAF3/TRAF6 levels and decreases IFNβ induction during RNA virus infection ( xref A)."
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