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OTUD1 activates Angiotensin-2. 6 / 6
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"Comprehensive histological analyses showed that OTUD1 expression enhances Ang II-responses manifesting as cardiac hypertrophy and fibrosis (Figure 7F-J, Figure S7E-O)."
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"These results demonstrate that OTUD1 promotes Ang II-induced cardiac remodeling and dysfunction through activating STAT3."
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"Our group has recently found that cardiomyocyte OTUD1 promoted angiotensin II‐ and TAC‐driven cardiac dysfunction, hypertrophy and fibrosis, while the role of OTUD1 was evaluated using the whole‐body OTUD1 knockout mice but not the myocardial‐specific OTUD1 knockout mice or BMT."
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"Conversely, increased expression of OTUD1 enhances Ang II-induced injuries in the heart."
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"OTUD1 increases Ang II-induced cardiomyocyte myocardial hypertrophy and fibrosis by regulating STAT3."
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"We also found that OTUD1 protein expression was elevated in Ang II-stimulated neonatal rat cardiac myocytes (NRCMs) (Figure 1F)."
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