IndraLab

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METTL3 activates OTUD1. 5 / 5
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"This study showed that OTUD1 deubiquitinates PDE5A, leading to its stabilization and increased cGMP degradation, which exacerbates cardiac hypertrophy and heart failure 58.Our research advances the understanding of OTUD1's role in cardiac hypertrophy and remodeling by elucidating the specific molecular mechanism involving the METTL3-mediated m6A modification of OTUD1 mRNA."
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"These findings support the notion that METTL3-mediated m6A modification enhances the stability and expression of OTUD1 mRNA."
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"Moreover, YTHDF1 had a direct interaction with OTUD1 mRNA (Figure S4J), which was reduced or strengthened by the knockdown (Figure 3M) or overexpression (Figure S4K) of METTL3, respectively."
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"Specifically, we demonstrate that METTL3-mediated m6A modification enhances OTUD1 mRNA stability, leading to increased OTUD1 protein expression."
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"To further validate role of METTL3 mediated OTUD1 RNA modification in cardiac hypertrophy in vivo, we used METTL3 inhibitor (STM2457) to treat AAV9-Otud1 mice."
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